The Architect is scheduled to main event the show on Sunday, April 7 against Brock Lesnar for the Universal Championship.
Rollins is reportedly struggling with a back injury but the true extent of the problem is not known.
With the Shield member being pulled from WWE live events it is more than possible his match against Lesnar may need to be rethought.
Rollins won the men’s Royal Rumble to book his main event slot at WrestleMania.
The 32-year-old did wrestle the night after on RAW against Dean Ambrose but has not stepped in the ring since.
He was written out of physical action by suffering six F5s at the hands of Lesnar later on the same evening.
It is unlikely we will see Rollins this Sunday at the Elimination Chamber or at Fastlane - the final pay-per-view event before WrestleMania.
You can expect to see more backstage segments or promos with Paul Heyman leading up to the Rollins vs Lesnar match until The Architect is cleared for action.
WWE owner Vince McMahon spoke about the impact of injuries on the company last week.
“The unfortunate aspect of sometimes in our business, is that our performers are not cartoons. They get hurt. This year, leading up to where we are now, we've had an inordinate number of injuries,” said McMahon.
“And when you have injuries, there's a whole bunch of them. Roman Reigns being the principle among them.
“In addition to that, we've had injuries to Sasha Banks, Becky Lynch, who is one of our top female performers, was injured.
“Kevin Owens, Sami Zayn, Bray Wyatt, Charlotte Flair, Alexa Bliss, Braun Strowman, Dean Ambrose, Ember Moon, Samoa Joe, Akam (from AOP), Jason Jordan, Fandango, Big Show, Seth Rollins. It's like we had all these injuries, which is really unusual for us, and they're characters.
“It's no different if you're writing a soap opera and all of a sudden your main character wasn't there. You're in the middle of production, what do you do? You very nimbly change the storyline, but it's not as good as the original one.
“Sometimes it is better because we're pretty good at it, but those are things that we're faced with, and one of the reasons why television ratings have dropped.
“And one of the reasons, obviously, from a live event standpoint, that's dropped too. Because if you don't have your favourites on television, obviously you can't see them at a live event either.”
The only other match announced for WrestleMania so far is RAW Women’s Champion Ronda Rousey taking on Becky Lynch.
There are strong rumours Charlotte Flair is set to be added to that match though and it will become a Triple Threat contest at MetLife Stadium in New York.