The biggest and the most significant contribution to Science is zero because zero is the number which helps the mathematicians and scientist for deriving the several useful formulas. If India's great scientist Aryabhatta did not discover the zero then the discovery of the computer which is leading several new inventions could not be possible as computer works on the binary system which is not completed without the zero.
2. Universal Series Bus (USB)
A man with many accolade under his belt, Ajay V. Bhatt (an Indian-American computer architect) made the USB, a little removable storage device that is capable of holding a large chunk of data storage and transfer. Plus, it’s easy to carry and use.
3. Plastic Surrgery
Plastic surgery is originated in India and it is the most vital milestone in the field of medicine . The great Indian Saint Sushuruta was the first person in the world who did the plastic surgery sucessfully he was also a great eye specialist. Several of the books written by him where he gave all the information about the plastic surgery was taken by the Britishers form the Nalanda University and by the help of these important instructions they developed this medical techinique.
Buttons were first used in Mohenjo-daro for ornamental purpose rather than for fastening. They were first used in the Indus Valley Civilization by 2000 BCE.
5. Radio/Wireless communication
We all know that Marconi received a Nobel Prize in Physics in 1909 for contribution to the development of wireless telegraphy. But the first public demonstration of radio waves for communication was made by Sir Jagdish Chandra Bose in 1895, two years prior to Marconi’s similar demonstration in England.
Sir Bose was posthumously credited (more than a century later) for his achievement. The fact remains that this discovery truly shaped the face of modern wireless communication.